{"id":14,"date":"2023-12-13T15:07:41","date_gmt":"2023-12-13T14:07:41","guid":{"rendered":"https:\/\/circame.fr\/?page_id=14"},"modified":"2026-02-09T18:23:39","modified_gmt":"2026-02-09T17:23:39","slug":"study-presentation","status":"publish","type":"page","link":"https:\/\/circame.fr\/index.php\/en\/study-presentation\/","title":{"rendered":"Study presentation"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"14\" class=\"elementor elementor-14\">\n\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-30eef34 e-flex e-con-boxed e-con e-parent\" data-id=\"30eef34\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;boxed&quot;}\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f5138f7 elementor-widget elementor-widget-image\" data-id=\"f5138f7\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 08-12-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"369\" src=\"https:\/\/circame.fr\/wp-content\/uploads\/2024\/09\/logo_CIRCAME_blanc_fond_bleu_titre_court_EN-768x369.png\" class=\"attachment-medium_large size-medium_large wp-image-272\" alt=\"\" srcset=\"https:\/\/circame.fr\/wp-content\/uploads\/2024\/09\/logo_CIRCAME_blanc_fond_bleu_titre_court_EN-768x369.png 768w, https:\/\/circame.fr\/wp-content\/uploads\/2024\/09\/logo_CIRCAME_blanc_fond_bleu_titre_court_EN-300x144.png 300w, https:\/\/circame.fr\/wp-content\/uploads\/2024\/09\/logo_CIRCAME_blanc_fond_bleu_titre_court_EN-1024x492.png 1024w, https:\/\/circame.fr\/wp-content\/uploads\/2024\/09\/logo_CIRCAME_blanc_fond_bleu_titre_court_EN-1536x738.png 1536w, https:\/\/circame.fr\/wp-content\/uploads\/2024\/09\/logo_CIRCAME_blanc_fond_bleu_titre_court_EN-2048x984.png 2048w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-80e333d e-flex e-con-boxed e-con e-parent\" data-id=\"80e333d\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;boxed&quot;}\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ab18303 elementor-widget elementor-widget-text-editor\" data-id=\"ab18303\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 08-12-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Circadian rhythm (CR) regulates body functions over the 24-hour day\/night period; sleep\/wake cycle is its most visible manifestation. The objective of <span style=\"color: #0646ad;\"><strong>CIRCAME<\/strong><\/span> is to identify circadian rhythm disturbances specific to Alzheimer\u2019s disease and related disorders.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e114123 e-flex e-con-boxed e-con e-parent\" data-id=\"e114123\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;boxed&quot;}\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-341402f e-con-full e-flex e-con e-child\" data-id=\"341402f\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;full&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-07b845e elementor-widget elementor-widget-text-editor\" data-id=\"07b845e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>A wrist-worn device, accelerometer worn over a period of 9 days, will be used to measure components of the circadian rhythm such as physical activity, sleep, chronotype (being a morning or evening person), or fragmentation of the sleep\/wake cycle.<\/p><p>The importance of circadian rhythm for Alzheimer\u2019s disease and related dementias will be compared to other individual factors, such as:<\/p><ul><li>lifestyle (household composition, tobacco consumption, etc.),<\/li><li>clinical measurements (blood pressure, weight, etc.),<\/li><li>biological measurements (cerebrospinal fluid biomarkers, plasma biomarkers, etc.),<\/li><li>health-related measures (medication, diseases, etc.).<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d9f6421 e-con-full e-flex e-con e-child\" data-id=\"d9f6421\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;full&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2ebb467 elementor-widget elementor-widget-image\" data-id=\"2ebb467\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"98\" height=\"149\" src=\"https:\/\/circame.fr\/wp-content\/uploads\/2023\/12\/accelero.png\" class=\"attachment-large size-large wp-image-75\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d85f313 e-flex e-con-boxed e-con e-parent\" data-id=\"d85f313\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;boxed&quot;}\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b2a8c92 elementor-widget elementor-widget-text-editor\" data-id=\"b2a8c92\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"color: #0646ad;\"><strong>The overarching aim of the CIRCAME study is to identify circadian rhythm signatures that along with individual characteristics (clinical, biomarkers, etc.) could be used to facilitate early screening of Alzheimer\u2019s disease and related disorders, and provide an indication on progression of disease. <\/strong><\/span><\/p><p>This study is recruiting patients from two Parisian clinical establishments of the \u201cAssistance Publique &#8211; H\u00f4pitaux de Paris\u201d (APHP):<\/p><ul><li><a href=\"https:\/\/centre-memoire.aphp.fr\/\">the Cognitive Neurology Center at Fernand-Widal \u2013 Lariboisi\u00e8re hospital<\/a><\/li><li><a href=\"https:\/\/hopital-bretonneau.aphp.fr\/bretonneau\/\">the Geriatric Day Hospital at Bretonneau hospital<\/a>\u00a0<\/li><\/ul><p>For patients able to visit the Cognitive Neurology Centre at Fernand Widal Hospital, two sub-studies are also proposed.<\/p><p>The first, called <span style=\"color: #0646ad;\"><strong>CIRCAME-EYE<\/strong><\/span>, consists of an examination of the retina in the form of photographs of the eye including a refractometry measurement, a fundus photo, and an OCT\/OCT-A (optical coherence tomography\/angiography). None of these measurements required the administration of eye drops. <span style=\"color: #0646ad;\"><strong>The aim of the CIRCAME-EYE sub-study is to examine whether microvascular dysfunction and the level of degeneration in the eye could be a marker of neurocognitive health.<\/strong><\/span><\/p><p>The second, called <span style=\"color: #0646ad;\"><strong>CIRCAME-EAR<\/strong><\/span>, involves detailed audiological tests that analyze hearing at the ear level (otoscopy, wideband tympanometry, pure-tone and speech audiometry in both quiet and noisy environments) as well as at the brain level (auditory evoked potentials, electroencephalogram with auditory stimulation). These tests are painless, have no side effects, and do not require the administration of any substances. <span style=\"color: #0646ad;\"><strong>The aim of the CIRCAME-EAR sub-study is to study peripheral and central auditory dysfunctions.<\/strong><\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Circadian rhythm (CR) regulates body functions over the 24-hour day\/night period; sleep\/wake cycle is its most visible manifestation. The objective of CIRCAME is to identify circadian rhythm disturbances specific to Alzheimer\u2019s disease and related disorders. A wrist-worn device, accelerometer worn over a period of 9 days, will be used to measure components of the circadian [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-14","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study presentation - WordPress<\/title>\n<meta name=\"description\" content=\"Presentation of the CIRCAME cohort\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/circame.fr\/index.php\/en\/study-presentation\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study presentation - 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