{"id":12,"date":"2023-12-13T15:11:18","date_gmt":"2023-12-13T14:11:18","guid":{"rendered":"https:\/\/circame.fr\/?page_id=12"},"modified":"2026-02-03T11:03:55","modified_gmt":"2026-02-03T10:03:55","slug":"circame-cohorte","status":"publish","type":"page","link":"https:\/\/circame.fr\/index.php\/circame-cohorte\/","title":{"rendered":"Pr\u00e9sentation de l&rsquo;\u00e9tude"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"12\" class=\"elementor elementor-12\">\n\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5f4aa4c e-flex e-con-boxed e-con e-parent\" data-id=\"5f4aa4c\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;boxed&quot;}\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d4d73f4 elementor-widget elementor-widget-image\" data-id=\"d4d73f4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 08-12-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"370\" src=\"https:\/\/circame.fr\/wp-content\/uploads\/2023\/12\/baniereetude-768x370.png\" class=\"attachment-medium_large size-medium_large wp-image-74\" alt=\"\" srcset=\"https:\/\/circame.fr\/wp-content\/uploads\/2023\/12\/baniereetude-768x370.png 768w, https:\/\/circame.fr\/wp-content\/uploads\/2023\/12\/baniereetude-300x144.png 300w, https:\/\/circame.fr\/wp-content\/uploads\/2023\/12\/baniereetude-1024x493.png 1024w, https:\/\/circame.fr\/wp-content\/uploads\/2023\/12\/baniereetude.png 1379w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6cee624 e-flex e-con-boxed e-con e-parent\" data-id=\"6cee624\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;boxed&quot;}\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22ca822 elementor-widget elementor-widget-text-editor\" data-id=\"22ca822\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 08-12-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p class=\"MsoNormal\" style=\"margin-left: -7.1pt; text-align: justify;\">Le rythme circadien r\u00e9gule les fonctions de l&rsquo;organisme sur la p\u00e9riode jour\/nuit de 24 heures ; le cycle veille\/sommeil en est la manifestation la plus visible. <span lang=\"fr\" style=\"background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;\">L\u2019\u00e9tude <b><span style=\"color: #0646ad;\">CIRCAME<\/span><\/b> a pour objectif d\u2019identifier les perturbations de rythme circadien sp\u00e9cifiques \u00e0 la maladie d\u2019Alzheimer et les maladies apparent\u00e9es.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7bb5c0f e-flex e-con-boxed e-con e-parent\" data-id=\"7bb5c0f\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;boxed&quot;}\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a57932e e-con-full e-flex e-con e-child\" data-id=\"a57932e\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;full&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c5be94 elementor-widget elementor-widget-text-editor\" data-id=\"8c5be94\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Un actim\u00e8tre (dispositif port\u00e9 au poignet mesurant l\u2019activit\u00e9) port\u00e9e sur une p\u00e9riode de 9 jours sera utilis\u00e9e pour mesurer les diff\u00e9rentes composantes du rythme circadien telles que l\u2019activit\u00e9 physique, le sommeil, le chronotype (\u00eatre plut\u00f4t du matin ou du soir), ou bien la fragmentation du cycle veille\/sommeil.<\/p><p>L\u2019importance du rythme circadien pour la maladie d\u2019Alzheimer et les maladies apparent\u00e9es sera compar\u00e9e \u00e0 celle d\u2019autres facteurs individuels, comme\u00a0:<\/p><ul><li>le mode de vie (composition du foyer, consommation de tabac, \u2026),<\/li><li>des mesures cliniques (pression art\u00e9rielle, poids, \u2026),<\/li><li>des mesures biologiques (biomarqueurs du liquide c\u00e9phalo-rachidien, plasmatiques, \u2026),<\/li><li>des mesures de sant\u00e9 (m\u00e9dicaments, maladies, \u2026).<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ecbe1e6 e-con-full e-flex e-con e-child\" data-id=\"ecbe1e6\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;full&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e5b0b34 elementor-widget elementor-widget-image\" data-id=\"e5b0b34\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"98\" height=\"149\" src=\"https:\/\/circame.fr\/wp-content\/uploads\/2023\/12\/accelero.png\" class=\"attachment-large size-large wp-image-75\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2491319 e-flex e-con-boxed e-con e-parent\" data-id=\"2491319\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;boxed&quot;}\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63cc5d5 elementor-widget elementor-widget-text-editor\" data-id=\"63cc5d5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"color: #0646ad;\"><strong>A terme,<\/strong> <strong>l\u2019objectif de l\u2019\u00e9tude CIRCAME est d\u2019identifier des signatures du rythme circadien qui accompagn\u00e9es d\u2019autres facteurs individuels (cliniques, biomarqueurs, \u2026) pourraient \u00eatre utilis\u00e9es pour faciliter le d\u00e9pistage pr\u00e9coce de la maladie d\u2019Alzheimer et des maladies apparent\u00e9es et fournir une indication de la progression de la maladie<\/strong>.<\/span><\/p><p>Cette \u00e9tude est men\u00e9e aupr\u00e8s de patients de deux \u00e9tablissements de l\u2019Assistance Publique &#8211; H\u00f4pitaux de Paris (APHP)\u00a0:<\/p><ul><li><a href=\"https:\/\/centre-memoire.aphp.fr\/\">le Centre de Neurologie Cognitive de l\u2019h\u00f4pital Fernand Widal \u2013 Lariboisi\u00e8re<\/a><\/li><li><a href=\"https:\/\/hopital-bretonneau.aphp.fr\/bretonneau\/\">l\u2019H\u00f4pital de Jour G\u00e9riatrique de l\u2019h\u00f4pital Bretonneau<\/a><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b371a71 e-flex e-con-boxed e-con e-parent\" data-id=\"b371a71\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;boxed&quot;}\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2299e03 elementor-widget elementor-widget-text-editor\" data-id=\"2299e03\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Pour les patients pouvant se rendre au Centre de Neurologie Cognitive \u00e0 l\u2019h\u00f4pital Fernand Widal, deux sous-\u00e9tudes sont \u00e9galement propos\u00e9es.\u00a0<\/p><p>La premi\u00e8re appel\u00e9e <span style=\"color: #0646ad;\"><strong>CIRCAME-EYE<\/strong><\/span>\u00a0consiste en un examen de la r\u00e9tine sous forme de photographies de l\u2019\u0153il comprenant une mesure de r\u00e9fractom\u00e9trie, un fond de l\u2019\u0153il et un OCT\/OCT-A (ou angiographie). Aucune de ces mesures ne n\u00e9cessitent l\u2019administration de gouttes. <span style=\"color: #0646ad;\"><strong>L\u2019objectif de la sous-\u00e9tude CIRCAME-EYE est d\u2019\u00e9tudier si des dysfonctionnements microvasculaires et du niveau de d\u00e9g\u00e9n\u00e9rescence au niveau de l\u2019\u0153il pourraient \u00eatre un marqueur de la sant\u00e9 neurocognitive<\/strong>.<\/span><\/p><p>La deuxi\u00e8me appel\u00e9e <span style=\"color: #0646ad;\"><strong>CIRCAME-EAR<\/strong><\/span> consiste \u00e0 la passation de tests audiologiques fins qui permettent une analyse de l\u2019audition au niveau de l\u2019oreille (otoscopie, tympanom\u00e9trie large-spectre, audiom\u00e9tries tonale et vocale (dans le silence et dans le bruit) mais \u00e9galement au niveau du cerveau (potentiels \u00e9voqu\u00e9s auditifs, \u00e9lectroenc\u00e9phalogramme avec stimulation auditive). Ces examens sont indolores, sans effet ind\u00e9sirable et ne n\u00e9cessitent aucune administration de produit. <b><span style=\"color: #0646ad;\"><strong>L\u2019objectif de la sous-\u00e9tude CIRCAME-EAR est d\u2019\u00e9tudier les dysfonctionnements auditifs p\u00e9riph\u00e9riques et centraux.<\/strong><\/span><\/b><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Le rythme circadien r\u00e9gule les fonctions de l&rsquo;organisme sur la p\u00e9riode jour\/nuit de 24 heures ; le cycle veille\/sommeil en est la manifestation la plus visible. L\u2019\u00e9tude CIRCAME a pour objectif d\u2019identifier les perturbations de rythme circadien sp\u00e9cifiques \u00e0 la maladie d\u2019Alzheimer et les maladies apparent\u00e9es. Un actim\u00e8tre (dispositif port\u00e9 au poignet mesurant l\u2019activit\u00e9) port\u00e9e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-12","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pr\u00e9sentation de l&#039;\u00e9tude - WordPress<\/title>\n<meta name=\"description\" content=\"Pr\u00e9sentation de l&#039;\u00e9tude CIRCAME.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/circame.fr\/index.php\/circame-cohorte\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pr\u00e9sentation de l&#039;\u00e9tude - 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